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KMID : 0352720090330010048
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Journal of Ginseng Research
2009 Volume.33 No. 1 p.48 ~ p.54
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Ginsenoside Rg1 Reduced Spontaneous Epileptiform Discharges and Behavioral Seizure in the Zebrafish
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Lee Yun-Kyoung
Lee Chang-Joong
Park Eun-Jin
Lee Sang-Hun
Kim Yeon-Hwa
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Abstract
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Epileptifrom discharges were induced in the telencephalon of the adult zebrafish via perfusion with pentylenetetrazole (PTZ), bicuculline methiodide, kainic acid-treated artificial cerebrospinal fluid (aCSF), and Mg2+-free aCSF. Ginseng total saponin [GTS (50 ㎍/ml)] was shown to attenuate the occurrence rate of epilpetiform discharges by 50-75%, compared to the control. Ginsenoside Rg₁ (130 ㎛) reduced the epileptiform discharges in the isolated telenephalon and delayed the occurrence of behavioral seizures observed from the adult zebrafish placed in the PTZ (10 mM)-containing aquarium water. However, Re was not effective in the suppression of epileptiform discharges and behavioral seizures. These results indicate that Rg1 may be useful in the control of epileptiform discharges and effective in controlling behavioral seizures, and that the zebrafish can be used as a model animal for the testing of potential anticonvulsant drugs.
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KEYWORD
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Panax ginseng, ginseng total saponin, ginsenoside Rg1, zebrafish telencephalon, anticonvulsant
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